Breast cancer risk with hormone replacement therapy

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Current or recent past users of hormonal replacement therapy HRT have a higher risk of being diagnosed with breast cancer. Before the link between HRT use and breast cancer risk was established, many postmenopausal women took HRT for many years to ease menopausal symptoms hot flashes, fatigue and to reduce bone loss. Still, many women continue to use HRT to handle bothersome menopausal symptoms.

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Hormones have an important role in our bodies. They play a role in controlling things like growth, fertility and our mood. After the menopause, the ovaries stop producing the female sex hormone oestrogen.

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H ormone replacement therapy HRT is the dinner party equivalent of politics and religion: a subject with strong and divided opinions certain to evoke spirited debate. Conflicting clinical data and discrepancies among studies have left the medical community with little to agree on. Women considering HRT should carefully consider the pros and cons unique to their personal health history, experts say.

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For decades, women have used hormone therapy to ease symptoms of menopause, such as hot flashes and sweating. But well-conducted studies have led many doctors to conclude that the risks of MHT often outweigh the benefits. It does not discuss other possible risks of MHT such as heart disease or stroke.

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Hormone replacement therapy and the risk of breast cancer: assessment of therapy acceptance in a cohort of previously treated breast cancer patients. Agnaldo Anelli; Daniel L. Estrogen can relieve vasomotor symptoms.

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MHT usually involves treatment with estrogen alone or estrogen plus progestina synthetic hormone whose effects are similar to those of progesterone. Women who have a uterus —that is, who have not had a hysterectomy —are generally prescribed estrogen plus progestin for MHT. This is because estrogen alone is associated with an increased risk of endometrial cancerbut estrogen plus progestin is not.

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By Debora MacKenzie. Hormone replacement therapy may be even more likely to cause breast cancer than we thought. But how much bigger is the risk, and is it so high that no one should take it?

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Hormone therapy was once routinely used to treat menopausal symptoms and protect long-term health. Then large clinical trials showed health risks. What does this mean for you? Hormone replacement therapy — medications containing female hormones to replace the ones the body no longer makes after menopause — is sometimes used to treat common menopausal symptoms, including hot flashes and vaginal discomfort.

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More than a decade after a massive study of hormone replacement therapy was halted due to higher rates of breast cancer, heart attack and stroke among women assigned to the drugs to treat menopausal symptoms, a new follow-up study has found those women had no higher risk of death as of than participants who took a placebo. It offers reassurance to postmenopausal women who took hormone replacement therapy during the trial that they have not increased their risk of dying. Overall, the researchers found that the risk of dying from any cause through the end of the follow-up period in was the same for women who had taken hormone therapy as for women who had taken a placebo.

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