Advanced breast cancer a

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The relative efficacies of cytotoxic chemotherapy regimens in the treatment of advanced breast cancer are generally assessed by comparing response rates in randomised trials. Treatment attempts to prolong survival but trials rarely demonstrate a statistically significant survival advantage: it has been argued that chemotherapy does not prolong survival. The correlation between response rates and survival has been examined by reviewing 79 comparisons between arms with unequal response rates in 50 published trials of chemotherapy in advanced breast cancer.

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Schoger died of metastatic breast cancer in May. Want to learn more about MBC? That everybody survives cancer now.

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Metastatic breast cancer also called stage IV is breast cancer that has spread to another part of the body, most commonly the liver, brain, bones, or lungs. Cancer cells can break away from the original tumor in the breast and travel to other parts of the body through the bloodstream or the lymphatic system, which is a large network of nodes and vessels that works to remove bacteria, viruses, and cellular waste products. Breast cancer can come back in another part of the body months or years after the original diagnosis and treatment.

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Explain the rationale for the multidisciplinary coordination of care for patients with locally advanced breast cancer. Identify the current standard of care for the treatment of locally advanced breast cancer. Locally advanced breast cancer remains a clinical challenge as the majority of patients with this diagnosis develop distant metastases despite appropriate therapy. Patients with locally advanced disease encompass a wide range of clinical scenarios including advanced primary tumors stage T4advanced nodal disease fixed axillary nodes or involvement of ipsilateral supraclavicular, infraclavicular, or internal mammary nodesand inflammatory carcinomas.

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Metastatic breast cancer also called stage IV or advanced breast cancer is not a specific type of breast cancer. It's the most advanced stage of breast cancer. Metastatic breast cancer is breast cancer that has spread beyond the breast and nearby lymph nodes to other organs in the body most often the bones, lungs, liver or brain.

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Stage 4 breast cancer refers to cancer that has spread beyond the breast tissue into other areas of the body. To understand the prognosis for stage 4 breast cancer, it helps to know something about the process of metastasis. In the case of breast cancer, receiving a stage 4 diagnosis may mean the cancer has reached organs outside of the breasts, such as your bones, lungs, liver, or even your brain.

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Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. Treating advanced breast cancer with metronomic chemotherapy: what is known, what is new and what is the future? Received 29 September

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Some of these relate to healthcare, such as managing the symptoms of the cancer, the side-effects of the treatment, and anxiety and depression. But people with advanced cancer also have other needs, which include effective communications with health professionals, emotional support from family and friends, and practical support to enable them, for instance, to stay working, access insurance, or get help with financial hardship. Women and some men with advanced breast cancer comprise one of the largest groups to face these issues, and they are the focus of the Advanced Breast Cancer consensus conference, now coming up to its third event ABC3in Lisbon in November.

Most women with stage IV breast cancer are treated with systemic therapy. This may include hormone therapy, chemotherapy, targeted therapy, or some combination of these. Local treatments such as surgery or radiation might also be used to help prevent or treat symptoms. Stage IV cancers have spread beyond the breast and nearby lymph nodes to other parts of the body.

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