Biology breast cancer

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Cancer is a complex disease involving many stages of development, often over long periods of time. However, a closer look at the biology of breast cancer can help us to understand why exposure to harmful chemicals such as EDCs matter and why they are of potential significance to breast cancer risk. DNA plays a central role in cancer development.

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Breast cancer in young women frequently presents with an aggressive phenotype, leading to a poorer prognosis than in older women. Addressing whether or not the biology of breast cancer in young women is truly unique is an important question, as it increases our understanding of the disease process, while informing the provision of appropriate optimal quality care for the young breast cancer patient. Breast cancer at a young age has been reported to pursue a more aggressive clinical course and to be associated with a poorer prognosis compared with disease in older women [ 1 ].

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NCBI Bookshelf. It has been estimated that innew cases of invasive breast cancer would be detected in the United States ACS, Women born in the United States have, on average, a one in eight

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Breast cancer is cancer that develops from breast tissue. Risk factors for developing breast cancer include being female, obesitylack of physical exercise, drinking alcoholhormone replacement therapy during menopauseionizing radiationearly age at first menstruationhaving children late or not at all, older age, prior history of breast cancer, and family history. The balance of benefits versus harms of breast cancer screening is controversial. A Cochrane review stated that it is unclear if mammographic screening does more good or harm.

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Cancer is a group of more than different diseases. Cancer occurs when, for unknown reasons, cells become abnormal and divide without control or order. All parts of the body are made up of cells that normally divide to produce more cells only when the body needs them.

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This article focuses on the major hormones and growth factors for which a critical role in normal mammary growth has been clearly defined. Examples of such factors include somatostatin, mammostatin, mammary-derived growth inhibitor MDGImammary-derived growth factor-1 MDGF-1inhibins, activins, androgens, glucocorticoids, vitamin D, thyroid hormones, ecosinoids, and oxytocin. Clearly, the hormonal regulation of breast cancer cell growth and survival is multifaceted and very complex.

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Key area: Secondary breast cancer. Secondary breast cancer — when the cancer spreads and tumours develop elsewhere in the body — cuts short the lives of around 1, women and men each month in the UK. There is still so much we need to know about how breast cancer cells escape from the breast tumourenter the blood stream and manage to seed new tumours in places such as the bone, lungs and brain. Understanding the intricate cellular processes that contribute to these events will lead the way to preventing and controlling secondary breast cancer.

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Breast cancer is a complex disease with no simple solution. That's why our researchers are tackling it from every angle. Learn more about our areas of focus and why each is critical to knowing how to fight cancer from the start, slow its progress and one day stop it from occurring altogether.

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