Some individuals may only develop one random episode that responds to treatment and resolves within one year. In some cases, a new episode does not occur or does not occur until many years later. Other individuals may develop chronic disease, in which episodes come and go, often years apart and with no symptoms in-between episodes.
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed.
Adult Still's disease is a rare type of inflammatory arthritis that features fevers, rash and joint pain. Some people have just one episode of adult Still's disease. In other people, the condition persists or recurs.
Some people may have only one bout of the illness and then recover, while in others the disease persists and may lead to permanent joint destruction and other serious health problems. Men and women are equally at risk. AOSD affects only a few people in every million.
Adult Still disease ASD is a rare illness that causes high fevers, rash, and joint pain. It may lead to long-term chronic arthritis. Adult Still disease is a severe version of juvenile idiopathic arthritis JIAwhich occurs in children.
There is also a pediatric version called systemic onset juvenile inflammatory arthritis SoJIA. AOSD is classified as an inflammatory illness that often causes fatigue and swelling in joints, tissues, organs, and lymph nodes. The primary symptoms include:.
Adult-onset Still's disease AOSD is a form of Still's diseasea rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking feversjoint painand a distinctive salmon-colored bumpy rash. The disease is considered a diagnosis of exclusion. AOSD may present in a similar manner to other inflammatory diseases and to autoimmune diseaseswhich must be ruled out before making the diagnosis. Prognosis is usually favorable but manifestations of the disease affecting the lungs, heart, or kidneys may occasionally cause severe life-threatening complications.
It shares characteristics of systemic-onset juvenile idiopathic arthritisbut it begins in adulthood. Inflammation may affect a few joints at first, but may advance to include more joints over time. Some people may have only one bout of the illness followed by lasting remission, while others may develop chronic arthritis.
Variables affecting treatment survival include loss of efficacy or adverse events, but also the decision to discontinue treatment after long-term clinical remission. Objectives: Aims of this study were: i to assess the drug retention rate DRR of ANA during a long-term follow-up looking for any difference related to the line of biologic treatment, the concomitant use of conventional disease modifying anti-rheumatic drugs cDMARDs and the different type of AOSD systemic versus chronic articular ; ii to identify predictive factors of lack of efficacy, loss of efficacy, and ANA withdrawal owing to long-term remission. Demographic, laboratory, clinical and therapeutic data related to the start of ANA baselinethe 3-month assessment and the last follow-up visit while on ANA treatment were retrospectively collected and statistically analyzed. The risk of losing ANA efficacy increases along with the number of swollen joints at the start of therapy, while the typical skin rash is a negative predictor of ANA withdrawal related to sustained remission.